Galectin-1 at the fetomaternal interface.
Galectin-1 at the fetomaternal interface prevents fetal loss by inducing immune regulatory mechanisms, including the apoptosis of Th1 and Th17 T cells and the induction of tolerogenic dendritic cells, which in turn promote the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo.
Galectin-1 at the fetomaternal interface prevents fetal loss by inducing immune regulatory mechanisms, including induction of immunosuppressive cytokines and tolerogenic dendritic cells, which in turn promote the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. This effect is regulated by progesterone in first trimester pregnancies.
Blois et al, Nat Med. 2007; Ramhorst et al, Glycobiology 2012.